Enhancement of Therapies for Glioblastoma (GBM) Using Nanoparticle-based Delivery Systems.

ABSTRACT: Glioblastoma multiforme (GBM) is the most aggressive type of malignant brain tumor. Current FDA-approved treatments include surgical resection, radiation, and chemotherapy, while hyperthermia, immunotherapy, and most relevantly, nanoparticle (NP)-mediated delivery systems or combinations thereof have shown promise in preclinical studies. Drug-carrying NPs are a promising approach to brain delivery as a result of their potential to facilitate the crossing of the blood-brain barrier (BBB) via two main types of transcytosis mechanisms: adsorptive-mediated transcytosis (AMT) and receptor-mediated transcytosis (RMT). Their ability to accumulate in the brain can thus provide local sustained release of tumoricidal drugs at or near the site of GBM tumors. NP-based drug delivery has the potential t

SUBMITTER: Wiwatchaitawee K 

PROVIDER: S-EPMC8092804 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature