Stabilizing the HIV-1 envelope glycoprotein State 2A conformation.

ABSTRACT: The HIV-1 envelope glycoprotein (Env) trimer [(gp120/gp41)₃] is a metastable complex expressed at the surface of viral particles and infected cells that samples different conformations. Before engaging CD4, Env adopts an antibody-resistant "closed" conformation (State 1). CD4 binding triggers an intermediate conformation (State 2) and then a more "open" conformation (State 3) that can be recognized by non-neutralizing antibodies (nnAbs) such as those that recognize the coreceptor binding site (CoRBS). Binding of antibodies to the CoRBS permits another family of nnAbs, the anti-cluster A family of Abs which target the gp120 inner domain, to bind and stabilize an asymmetric conformation (State 2A). Cells expressing Env in this conformation are susceptible to antibody-dependent cel

SUBMITTER: Vezina D 

PROVIDER: S-EPMC8092833 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature