Classical swine fever virus N^pro antagonises IRF3 to prevent IFN-independent TLR3 and RIG-I-mediated apoptosis.

ABSTRACT: Classical swine fever virus (CSFV) is the causative agent of classical swine fever, a notifiable disease of economic importance that causes severe leukopenia, fever and haemorrhagic disease in domesticated pigs and wild boar across the globe. CSFV has been shown to antagonise the induction of type I IFN, partly through a function of its N-terminal protease (N^pro) which binds IRF3 and targets it for proteasomal degradation. Additionally, N^pro has been shown to antagonise apoptosis triggered by the dsRNA-homolog poly(I:C), however the exact mechanism by which this is achieved has not been fully elucidated. In this study we confirm the ability of N^pro to inhibit dsRNA-mediated apoptosis and show that N^pro is also able to antagonise Sendai virus-medi

SUBMITTER: Hardy S 

PROVIDER: S-EPMC8092839 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature