Stem Cells and Spinal Fusion.

ABSTRACT:

Background

This manuscript is a review of the literature investigating the use of mesenchymal stem cells (MSCs) being applied in the setting of spinal fusion surgery. We mention the rates of pseudarthrosis, discuss current bone grafting options, and examine the preclinical and clinical outcomes of utilizing MSCs to assist in successfully fusing the spine.

Methods

A thorough literature review was conducted to look at current and previous preclinical and clinical studies using stem cells for spinal fusion augmentation. Searches for PubMed/MEDLINE and ClinicalTrials.gov through January 2021 were conducted for literature mentioning stem cells and spinal fusion.

Results

All preclinical and clinical studies investigating MSC use in spinal fusion were examined. We found 19 p

SUBMITTER: Stephan SR 

PROVIDER: S-EPMC8092934 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature