Bias and Precision of Parameter Estimates from Models Using Polygenic Scores to Estimate Environmental and Genetic Parental Influences.

ABSTRACT: In a companion paper Balbona et al. (Behav Genet, in press), we introduced a series of causal models that use polygenic scores from transmitted and nontransmitted alleles, the offspring trait, and parental traits to estimate the variation due to the environmental influences the parental trait has on the offspring trait (vertical transmission) as well as additive genetic effects. These models also estimate and account for the gene-gene and gene-environment covariation that arises from assortative mating and vertical transmission respectively. In the current study, we simulated polygenic scores and phenotypes of parents and offspring under genetic and vertical transmission scenarios, assuming two types of assortative mating. We instantiated the models from our companion paper in the OpenMx s

SUBMITTER: Kim Y 

PROVIDER: S-EPMC8093160 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature