Manganese salts function as potent adjuvants.

ABSTRACT: Aluminum-containing adjuvants have been used for nearly 100 years to enhance immune responses in billions of doses of vaccines. To date, only a few adjuvants have been approved for use in humans, among which aluminum-containing adjuvants are the only ones widely used. However, the medical need for potent and safe adjuvants is currently continuously increasing, especially those triggering cellular immune responses for cytotoxic T lymphocyte activation, which are urgently needed for the development of efficient virus and cancer vaccines. Manganese is an essential micronutrient required for diverse biological activities, but its functions in immunity remain undefined. We previously reported that Mn²⁺ is important in the host defense against cytosolic dsDNA by facilitating cGAS-STIN

SUBMITTER: Zhang R 

PROVIDER: S-EPMC8093200 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature