Ontology highlight
ABSTRACT:
SUBMITTER: Criado-Marrero M
PROVIDER: S-EPMC8093247 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Criado-Marrero Marangelie M Gebru Niat T NT Gould Lauren A LA Blazier Danielle M DM Vidal-Aguiar Yamile Y Smith Taylor M TM Abdelmaboud Salma S SS Shelton Lindsey B LB Wang Xinming X Dahrendorff Jan J Beaulieu-Abdelahad David D Dickey Chad A CA Blair Laura J LJ
NPJ aging and mechanisms of disease 20210503 1
Abnormal accumulation of hyperphosphorylated tau induces pathogenesis in neurodegenerative diseases, like Alzheimer's disease. Molecular chaperones with peptidyl-prolyl cis/trans isomerase (PPIase) activity are known to regulate these processes. Previously, in vitro studies have shown that the 52 kDa FK506-binding protein (FKBP52) interacts with tau inducing its oligomerization and fibril formation to promote toxicity. Thus, we hypothesized that increased expression of FKBP52 in the brains of ta ...[more]