The microbiota is dispensable for the early stages of peripheral regulatory T cell induction within mesenteric lymph nodes.

ABSTRACT: Intestinal Foxp3⁺ regulatory T cell (Treg) subsets are crucial players in tolerance to microbiota-derived and food-borne antigens, and compelling evidence suggests that the intestinal microbiota modulates their generation, functional specialization, and maintenance. Selected bacterial species and microbiota-derived metabolites, such as short-chain fatty acids (SCFAs), have been reported to promote Treg homeostasis in the intestinal lamina propria. Furthermore, gut-draining mesenteric lymph nodes (mLNs) are particularly efficient sites for the generation of peripherally induced Tregs (pTregs). Despite this knowledge, the direct role of the microbiota and their metabolites in the early stages of pTreg induction within mLNs is not fully elucidated. Here, using an adoptive transfer-

SUBMITTER: Wiechers C 

PROVIDER: S-EPMC8093251 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature