Dataset Information

Implications of Tumor Characteristics and Treatment Modality on Local Recurrence and Functional Outcomes in Children With Chest Wall Sarcoma: A Pediatric Surgical Oncology Research Collaborative Study.

ABSTRACT:

Objective

To determine the impact of tumor characteristics and treatment approach on (1) local recurrence, (2) scoliosis development, and (3) patient-reported quality of life in children with sarcoma of the chest wall.

Summary of background data

Children with chest wall sarcoma require multimodal therapy including chemotherapy, surgery, and/or radiation. Despite aggressive therapy which places them at risk for functional impairment and scoliosis, these patients are also at significant risk for local recurrence.

Methods

A multi-institutional review of 175 children (median age 13 years) with chest wall sarcoma treated at seventeen Pediatric Surgical Oncology Research Collaborative institutions between 2008 and 2017 was performed. Patient-reported quality of life was assessed prospectively using PROMIS surveys.

Results

The most common diagnoses were Ewing sarcoma (67%) and osteosarcoma (9%). Surgical resection was performed in 85% and radiation in 55%. A median of 2 ribs were resected (interquartile range = 1-3), and number of ribs resected did not correlate with margin status ( P = 0.36). Local recurrence occurred in 23% and margin status was the only predictive factor(HR 2.24, P = 0.039). With a median follow-up of 5 years, 13% developed scoliosis (median Cobb angle 26) and 5% required corrective spine surgery. Scoliosis was associated with posteriorrib resection (HR 8.43; P= 0.003) and increased number of ribs resected (HR 1.78; P = 0.02). Overall, patient-reported quality of life is not impaired after chest wall tumor resection.

Conclusions

Local recurrence occurs in one-quarter of children with chest wall sarcoma and is independent of tumor type. Scoliosis occurs in 13% of patients, but patient-reported quality of life is excellent.

SUBMITTER: Harris CJ

PROVIDER: S-EPMC8093319 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Publications

Implications of Tumor Characteristics and Treatment Modality on Local Recurrence and Functional Outcomes in Children With Chest Wall Sarcoma: A Pediatric Surgical Oncology Research Collaborative Study.

Harris Courtney J CJ Helenowski Irene I Murphy Andrew J AJ Mansfield Sara A SA LaQuaglia Michael P MP Heaton Todd E TE Cavalli Michele M Murphy Joseph T JT Newman Erika A EA Overmen Richard E RE Kartal Tanvi T TT Cooke-Barber J J Donaher Addison A Malek Marcus M MM Kalsi Ranjeet R Kim Eugene S ES Zobel Michael J MJ Goodhue Catherine J CJ Naik-Mathuria Bindi J BJ Jefferson Imory N IN Roach Jonathan P JP Mata Claudia C Piché Nelson N Joharifard Shahrzad S Sultan Serge S Short Scott S SS Meyers Rebecka L RL Bleicher Josh J Le Hau D HD Janek Kevin K Bütter Andreana A Davidson Jacob J Aldrink Jennifer H JH Richards Holden W HW Tracy Elisabeth T ET Commander Sarah J SJ Fialkowski Elizabeth A EA Troutt Misty M Dasgupta Roshni R Lautz Timothy B TB

Annals of surgery 20201104 6

<h4>Objective</h4>To determine the impact of tumor characteristics and treatment approach on (1) local recurrence, (2) scoliosis development, and (3) patient-reported quality of life in children with sarcoma of the chest wall.<h4>Summary of background data</h4>Children with chest wall sarcoma require multimodal therapy including chemotherapy, surgery, and/or radiation. Despite aggressive therapy which places them at risk for functional impairment and scoliosis, these patients are also at signifi ...[more]

PMID: 33156070

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Dataset Information

Implications of Tumor Characteristics and Treatment Modality on Local Recurrence and Functional Outcomes in Children With Chest Wall Sarcoma: A Pediatric Surgical Oncology Research Collaborative Study.

Objective

Summary of background data

Methods

Results

Conclusions

Publications

Implications of Tumor Characteristics and Treatment Modality on Local Recurrence and Functional Outcomes in Children With Chest Wall Sarcoma: A Pediatric Surgical Oncology Research Collaborative Study.

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