Hyperoxemia and Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage.

ABSTRACT:

Background

Cerebral vasospasm is a major contributor to disability and mortality after aneurysmal subarachnoid hemorrhage. Oxidation of cell-free hemoglobin plays an integral role in neuroinflammation and is a suggested source of tissue injury after aneurysm rupture. This study sought to determine whether patients with subarachnoid hemorrhage and cerebral vasospasm were more likely to have been exposed to early hyperoxemia than those without vasospasm.

Methods

This single-center retrospective cohort study included adult patients presenting with aneurysmal subarachnoid hemorrhage to Vanderbilt University Medical Center between January 2007 and December 2017. Patients with an ICD-9/10 diagnosis of aneurysmal subarachnoid hemorrhage were initially identified (N = 441) and subse

SUBMITTER: Reynolds RA 

PROVIDER: S-EPMC8093321 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature