Vaccine Inoculation Route Modulates Early Immunity and Consequently Antigen-Specific Immune Response.

ABSTRACT: Vaccination is one of the most efficient public healthcare measures to fight infectious diseases. Nevertheless, the immune mechanisms induced in vivo by vaccination are still unclear. The route of administration, an important vaccination parameter, can substantially modify the quality of the response. How the route of administration affects the generation and profile of immune responses is of major interest. Here, we aimed to extensively characterize the profiles of the innate and adaptive response to vaccination induced after intradermal, subcutaneous, or intramuscular administration with a modified vaccinia virus Ankara model vaccine in non-human primates. The adaptive response following subcutaneous immunization was clearly different from that following intradermal or intramuscul

SUBMITTER: Rosenbaum P 

PROVIDER: S-EPMC8093451 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature