Gene Expression Classifier Reveals Prognostic Osteosarcoma Microenvironment Molecular Subtypes.

ABSTRACT: Osteosarcoma (OSA) is the most common bone malignancy and displays high heterogeneity of molecular phenotypes. This study aimed to characterize the molecular features of OSA by developing a classification system based on the gene expression profile of the tumor microenvironment. Integrative analysis was performed using specimens and clinical information for OSA patients from the TARGET program. Using a matrix factorization method, we identified two molecular subtypes significantly associated with prognosis, S1 (infiltration type) and S2 (escape type). Both subtypes displayed unique features of functional significance features and cellular infiltration characteristics. We determined that immune and stromal infiltrates were abundant in subtype S1 compare to that in subtype S2. Furthermore, h

SUBMITTER: Song YJ 

PROVIDER: S-EPMC8093635 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature