The Links of Ghrelin to Incretins, Insulin, Glucagon, and Leptin After Bariatric Surgery.

ABSTRACT: Type 2 diabetes mellitus (T2DM) is one of the most prominent and socially significant problems. The present study aimed to identify the mechanisms of interaction of critical regulators of carbohydrate metabolism using bioinformatics and experimental methods and to assess their influence on the development of T2DM. We conducted an in silico search for the relationship of hormones and adipokines and performed functional annotation of the receptors for ghrelin and incretins. Hormones and adipokines were assessed in the plasma of obese patients with and without T2DM as well as after laparoscopic sleeve gastrectomy (LSG) and Roux-en-Y gastric bypass (RYGB) surgeries. Incretin- and ghrelin-associated functions and metabolic processes were discovered. Low ghrelin levels were observed in ob

SUBMITTER: Skuratovskaia D 

PROVIDER: S-EPMC8093791 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature