Exploring new uses for existing drugs: innovative mechanisms to fund independent clinical research.

ABSTRACT:

Background

Finding new therapeutic uses for existing medicines could lead to safe, affordable and timely new treatment options for patients with high medical needs. However, due to a lack of economic incentives, pharmaceutical developers are rarely interested to invest in research with approved medicines, especially when they are out of basic patent or regulatory protection. Consequently, potential new uses for these medicines are mainly studied in independent clinical trials initiated and led by researchers from academia, research institutes, or collaborative groups. Yet, additional financial support is needed to conduct expensive phase III clinical trials to confirm the results from exploratory research.

Methods

In this study, scientific and grey literature was searched to

SUBMITTER: Verbaanderd C 

PROVIDER: S-EPMC8093905 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature