Differential expression of Notch related genes in dental pulp stem cells and stem cells isolated from apical papilla.

ABSTRACT: Although dental pulp and apical papilla are originated from neural crest cells, these tissues exhibit distinct characteristics. Notch signaling is one of the known signaling pathways regulating stemness and behaviors of stem cells. The aim of this study was to examine Notch signaling related gene expression profile comparing between coronal pulp tissues and apical pulp complex. Results demonstrated that coronal pulp tissue had higher expression levels of various genes in Notch pathway. However, NOTCH2, MAML2, DTX4, and NEDD4 mRNA levels were significantly lower in coronal pulp tissue than those of apical pulp complex. Furthermore, dental pulp stem cells (DPSCs) and stem cells isolated from apical papilla (SCAPs) were isolated and characterized. These two cell ty

SUBMITTER: Damrongsri D 

PROVIDER: S-EPMC8093932 | biostudies-literature | 2021 Jul-Sep

REPOSITORIES: biostudies-literature