Risk of Persistent Disability in Patients With Pediatric-Onset Multiple Sclerosis.

ABSTRACT:

Importance

Availability of new disease-modifying therapies (DMTs) and changes of therapeutic paradigms have led to a general improvement of multiple sclerosis (MS) prognosis in adults. It is still unclear whether this improvement also involves patients with pediatric-onset MS (POMS), whose early management is more challenging.

Objective

To evaluate changes in the prognosis of POMS over time in association with changes in therapeutic and managing standards.

Design, setting, and participants

Retrospective, multicenter, observational study. Data were extracted and collected in May 2019 from the Italian MS Registry, a digital database including more than 59 000 patients. Inclusion criteria were MS onset before age 18 years, diagnosis before January 2014, and disease durat

SUBMITTER: Baroncini D 

PROVIDER: S-EPMC8094039 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature