Alcohol-induced lipid dysregulation impairs glycolytic responses to LPS in alveolar macrophages.

ABSTRACT: Several conditions are marked by increased susceptibility to, and enhanced severity of, bacterial infections. Alcohol use disorder, one of these conditions, is known to predispose to bacterial pneumonia by suppressing the lung's innate immune system, and more specifically by disrupting critical alveolar macrophage (AM) functions. Recently, we established that chronic ethanol consumption also perturbs surfactant lipid homeostasis in the lung and that elevated concentrations of free fatty acids contribute to blocking essential AM functions, such as agonist-induced cytokine expression. In this study, we extend these observations by showing that elevated free fatty acid levels impair metabolic responses to lipopolysaccharide (LPS) in AMs. In particular, we show that the glycolytic reprogrammin

SUBMITTER: Slovinsky WS 

PROVIDER: S-EPMC8094043 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature