Urinary selective serotonin reuptake inhibitors across critical windows of pregnancy establishment: a prospective cohort study of fecundability and pregnancy loss.

ABSTRACT:

Objective

To prospectively investigate the association of selective serotonin reuptake inhibitor (SSRI) exposure through critical windows of pregnancy establishment with fecundability and pregnancy loss.

Design

Prospective cohort study using longitudinal urine measurements of common SSRIs while women are actively trying to conceive.

Setting

Four clinical sites.

Patient(s)

A total of 1,228 women without uncontrolled depression/anxiety, attempting natural conception while participating in a randomized trial of preconception-initiated low-dose aspirin.

Interventions(s)

Not applicable.

Main outcome measure(s)

Urinary SSRIs (fluoxetine, sertraline, escitalopram/citalopram) were measured while trying to conceive and, for women who became pregnant, at we

SUBMITTER: Sjaarda LA 

PROVIDER: S-EPMC8094179 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature