Pancreatic enzyme replacement therapy for people with cystic fibrosis.

ABSTRACT:

Background

Most people with cystic fibrosis (CF) (80% to 90%) need pancreatic enzyme replacement therapy (PERT) to prevent malnutrition. Enzyme preparations need to be taken whenever food is taken, and the dose needs to be adjusted according to the food consumed. A systematic review on the efficacy and safety of PERT is needed to guide clinical practice, as there is variability between centres with respect to assessment of pancreatic function, time of commencing treatment, dose and choice of supplements. This is an updated version of a published review.

Objectives

To evaluate the efficacy and safety of PERT in children and adults with CF and to compare the efficacy and safety of different formulations of PERT and their appropriateness in different age groups. Also, to compar

SUBMITTER: Somaraju URR 

PROVIDER: S-EPMC8094413 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature