Dataset Information

A novel surgical approach for hypopharyngeal carcinoma resection via the paraglottic space.

ABSTRACT:

Background

Conservative surgery has proven advantageous in controlling hypopharyngeal squamous cell carcinoma (HSCC) and preserving speech and swallowing function in carefully selected patients, typically with early T-stages diseases. A variety of modified surgical procedures or techniques have been proposed.

Methods

In this study, we present a novel surgical approach for hypopharyngeal carcinoma resection utilizing the paraglottic space.

Results

The paraglottic space approach can help expose neoplasms under direct vision and save mucosa during surgery while sufficiently preserving laryngeal function, thus benefiting postoperative swallowing and reducing complications. A large cohort of 426 patients with HSCC underwent surgical treatment at our institution using this approach, demonstrating an overall survival (OS) rate of 52.3% and low incidences of postoperative complications.

Conclusions

This surgical approach can be applied in patients with the lesions that do not involve the paraglottic space.

SUBMITTER: Li W

PROVIDER: S-EPMC8094522 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Publications

A novel surgical approach for hypopharyngeal carcinoma resection via the paraglottic space.

Li Wenming W Wei Dongmin D Qian Ye Y Cao Shengda S Liu Dayu D Lei Dapeng D Pan Xinliang X

BMC surgery 20210503 1

<h4>Background</h4>Conservative surgery has proven advantageous in controlling hypopharyngeal squamous cell carcinoma (HSCC) and preserving speech and swallowing function in carefully selected patients, typically with early T-stages diseases. A variety of modified surgical procedures or techniques have been proposed.<h4>Methods</h4>In this study, we present a novel surgical approach for hypopharyngeal carcinoma resection utilizing the paraglottic space.<h4>Results</h4>The paraglottic space appro ...[more]

PMID: 33941151

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Project description:BackgroundFew reports from China provide confirmed evidence of the effectiveness of the larynx preservation strategy compared with surgery on the treatment of laryngeal and hypopharyngeal cancers. This study assessed the clinical outcomes of patients with locally advanced laryngeal and hypopharyngeal cancers treated with larynx preservation and determined the optimal larynx preservation procedure.MethodsData of 1,494 patients treated with total laryngectomy or larynx preservation between 2006 and 2014 were retrieved from the database of Sun-Yat Sen University Cancer Center in Guangzhou, China, and 366 eligible patients were selected for final analysis. The clinical outcomes of 228 patients received total laryngectomy and 138 patients received larynx preservation treatments, which comprises induction followed by radiotherapy and concurrent radio-chemotherapy, were compared.ResultsThere was no statistical difference in the 3-, 5-, and 10-year PFS and OS in patients received larynx preservation compared with patients treated with laryngectomy. With respect to T stage, a better overall OS in T2-stage disease (P = 0.036) but poorer PFS (P = 0.005) in T3-stage disease was observed in the larynx preservation group compared with the surgery group in Univariate analysis. T3-stage disease had poorer PFS in multivariable analysis (P = 0.022). With larynx preservation intent, induction chemotherapy followed by radiotherapy showed no advantage in the control of disease progression and survival compared with concurrent chemoradiotherapy. The patient subpopulations who received efficacy assessment after induction chemotherapy exhibited significantly longer PFS and OS compared with those without efficacy assessment.ConclusionsThis is the largest sample size study on larynx preservation treatment for laryngeal and hypopharyngeal cancers in China. Our results indicated that larynx preservation treatments did not jeopardize the survival of patients with advanced resectable laryngeal or hypopharyngeal cancers. Efficacy assessment should be emphasized in induction chemotherapy.

Dataset Information

A novel surgical approach for hypopharyngeal carcinoma resection via the paraglottic space.

Background

Methods

Results

Conclusions

Publications

A novel surgical approach for hypopharyngeal carcinoma resection via the paraglottic space.

Similar Datasets

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