Role of epigenetics in unicellular to multicellular transition in Dictyostelium.

ABSTRACT:

Background

The evolution of multicellularity is a critical event that remains incompletely understood. We use the social amoeba, Dictyostelium discoideum, one of the rare organisms that readily transits back and forth between both unicellular and multicellular stages, to examine the role of epigenetics in regulating multicellularity.

Results

While transitioning to multicellular states, patterns of H3K4 methylation and H3K27 acetylation significantly change. By combining transcriptomics, epigenomics, chromatin accessibility, and orthologous gene analyses with other unicellular and multicellular organisms, we identify 52 conserved genes, which are specifically accessible and expressed during multicellular states. We validated that four of these genes, including the H3K27 deace

SUBMITTER: Wang SY 

PROVIDER: S-EPMC8094536 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature