M⁶A-related lncRNAs are potential biomarkers for predicting prognoses and immune responses in patients with LUAD.

ABSTRACT: Lung adenocarcinoma (LUAD) is the most frequent subtype of lung cancer worldwide. However, the survival rate of LUAD patients remains low. N6-methyladenosine (m⁶A) and long noncoding RNAs (lncRNAs) play vital roles in the prognostic value and the immunotherapeutic response of LUAD. Thus, discerning lncRNAs associated with m⁶A in LUAD patients is critical. In this study, m⁶A-related lncRNAs were analyzed and obtained by coexpression. Univariate, least absolute shrinkage and selection operator (LASSO), and multivariate Cox regression analyses were conducted to construct an m⁶A-related lncRNA model. Kaplan-Meier analysis, principal-component analysis (PCA), functional enrichment annotation, and nomogram were used to analyze the risk model. Finally,

SUBMITTER: Xu F 

PROVIDER: S-EPMC8094594 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature