Transient peripheral immune response and central nervous system leaky compartmentalization in a viral model for multiple sclerosis.

ABSTRACT: Theiler's virus-induced demyelination represents an important animal model to study the chronic-progressive form of multiple sclerosis (MS). The aim of the present study was to identify specific genes and pathways in the deep cervical lymph node (cLN) and spleen of experimentally infected SJL-mice, using DNA microarrays. Analyses identified 387 genes in the deep cLN and only 6 genes in the spleen of infected animals. The lymph node presented 27.4% of genes with fold changes +/-1.5 at 14 days post infection (dpi) and a reduced transcription at later time points. K-means clustering analyses resulted in five clusters. Accordingly, functional annotation revealed that the B-cell immune response pathway was the most up-regulated cluster at the early phase. Additionally, an increase of CD68- and

SUBMITTER: Navarrete-Talloni MJ 

PROVIDER: S-EPMC8094647 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature