Nutrient availability regulates proline/alanine transporters in Trypanosoma brucei.

ABSTRACT: Trypanosoma brucei is a species of unicellular parasite that can cause severe diseases in livestock and humans, including African trypanosomiasis and Chagas disease. Adaptation to diverse environments and changes in nutritional conditions is essential for T. brucei to establish an infection when changing hosts or during invasion of different host tissues. One such adaptation is the ability of T. brucei to rapidly switch its energy metabolism from glucose metabolism in the mammalian blood to proline catabolism in the insect stages and vice versa. However, the mechanisms that support the parasite's response to nutrient availability remain unclear. Using RNAseq and qRT-PCR, we investigated the response of T. brucei to amino acid or glucose starvation and found increased mRNA levels of several

SUBMITTER: Haindrich AC 

PROVIDER: S-EPMC8094907 | biostudies-literature | 2021 Jan-Jun

REPOSITORIES: biostudies-literature