Roles of Cholesterol in Early and Late Steps of the Nipah Virus Membrane Fusion Cascade.

ABSTRACT: Cholesterol has been implicated in various viral life cycle steps for different enveloped viruses, including viral entry into host cells, cell-cell fusion, and viral budding from infected cells. Enveloped viruses acquire their membranes from their host cells. Although cholesterol has been associated with the binding and entry of various enveloped viruses into cells, cholesterol's exact function in the viral-cell membrane fusion process remains largely elusive, particularly for the paramyxoviruses. Furthermore, paramyxoviral fusion occurs at the host cell membrane and is essential for both virus entry (virus-cell fusion) and syncytium formation (cell-cell fusion), central to viral pathogenicity. Nipah virus (NiV) is a deadly member of the Paramyxoviridae family, which also includes Hendra,

SUBMITTER: Contreras EM 

PROVIDER: S-EPMC8094960 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature