Renin inhibitors versus angiotensin converting enzyme (ACE) inhibitors for primary hypertension.

ABSTRACT:

Background

Renin inhibitors (RIs) reduce blood pressure more than placebo, with the magnitude of this effect thought to be similar to that for angiotensin converting enzyme (ACE) inhibitors. However, a drug's efficacy in lowering blood pressure cannot be considered as a definitive indicator of its effectiveness in reducing mortality and morbidity. The effectiveness and safety of RIs compared to ACE inhibitors in treating hypertension is unknown.

Objectives

To evaluate the benefits and harms of renin inhibitors compared to ACE inhibitors in people with primary hypertension.

Search methods

The Cochrane Hypertension Group Information Specialist searched the following databases for randomized controlled trials up to August 2020: the Cochrane Hypertension Specialized Regis

SUBMITTER: Wang GM 

PROVIDER: S-EPMC8094968 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature