Integrating 3D structural information into systems biology.

ABSTRACT: Systems biology is a data-heavy field that focuses on systems-wide depictions of biological phenomena necessarily sacrificing a detailed characterization of individual components. As an example, genome-wide protein interaction networks are widely used in systems biology and continuously extended and refined as new sources of evidence become available. Despite the vast amount of information about individual protein structures and protein complexes that has accumulated in the past 50 years in the Protein Data Bank, the data, computational tools, and language of structural biology are not an integral part of systems biology. However, increasing effort has been devoted to this integration, and the related literature is reviewed here. Relationships between proteins that are detected via structu

SUBMITTER: Murray D 

PROVIDER: S-EPMC8095114 | biostudies-literature | 2021 Jan-Jun

REPOSITORIES: biostudies-literature