Discovery and characterization of small-molecule inhibitors of NLRP3 and NLRC4 inflammasomes.

ABSTRACT: Inflammasomes are macromolecular complexes involved in the host response to external and endogenous danger signals. Inflammasome-mediated sterile inflammation plays a central role in several human conditions such as autoimmune diseases, type-2 diabetes, and neurodegenerative disorders, indicating inflammasomes could be appealing therapeutic targets. Previous work has demonstrated that inhibiting the ATPase activity of the nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain-containing protein 3 (NLRP3), disrupts inflammasome assembly and function. However, there is a necessity to find new potent compounds with therapeutic potential. Here we combine computational modeling of the target and virtual screening to discover a group of novel compounds predicted to inhib

SUBMITTER: Sebastian-Valverde M 

PROVIDER: S-EPMC8095128 | biostudies-literature | 2021 Jan-Jun

REPOSITORIES: biostudies-literature