Early epitope-specific IgE antibodies are predictive of childhood peanut allergy.

ABSTRACT:

Background

Peanut allergy is characterized by the development of IgE against peanut antigen.

Objective

We sought to evaluate the evolution of epitope-specific (es)IgE and esIgG₄ in a prospective cohort of high-risk infants to determine whether antibody profiles can predict peanut allergy after age 4 years.

Methods

The end point was allergy status at age 4⁺ years; samples from 293 children were collected at age 3 to 15 months and 2 to 3 and 4⁺ years. Levels of specific (s)IgE and sIgG₄ to peanut and component proteins, and 50 esIgE and esIgG₄ were quantified. Changes were analyzed with mixed-effects models. Machine learning algorithms were developed to identify a combination of antigen- and epitope-specific antibod

SUBMITTER: Suprun M 

PROVIDER: S-EPMC8095129 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature