Pharmaceutical Aspects and Clinical Evaluation of COVID-19 Vaccines.

ABSTRACT: COVID-19, the disease caused by the novel severe acute respiratory syndrome-associated coronavirus 2 (SARS-CoV-2), was first detected in December 2019 and has since morphed into a global pandemic claiming over 2.4 million human lives and severely impacting global economy. The race for a safe and efficacious vaccine was thus initiated with government agencies as well as major pharmaceutical companies as frontrunners. An ideal vaccine would activate multiple arms of the adaptive immune system to generate cytotoxic T cell responses as well as neutralizing antibody responses, while avoiding pathological or deleterious immune responses that result in tissue damage or exacerbation of the disease. Developing an effective vaccine requires an inter-disciplinary effort involving virology, protein bi

SUBMITTER: Hofman K 

PROVIDER: S-EPMC8095160 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature