Nanocomposite hyaluronic acid-based hydrogel for the treatment of esophageal fistulas.

ABSTRACT: Fistulas are abnormal connections between two body parts that can impair the quality of life. The use of biological glues represents the least invasive procedure to fill the fistula; however, it is limited by the need of multiple injections, the persistence of infection and the failure in the treatment of high-output fistulas. We describe herein the use of an injectable nanocomposite hydrogel that is able to form in situ a tissue-mimicking matrix as an innovative material for the treatment of esophageal fistulas. Injectable hydrogels that have the dual advantage of being implantable with a minimally invasive approach and of adapting their shape to the target cavity, while the introduction of mesoporous silica nanoparticles opens the possibility of drug/biomolecules delivery. The hyd

SUBMITTER: Piantanida E 

PROVIDER: S-EPMC8095189 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature