Multi-Omics Approaches to Define Calcific Aortic Valve Disease Pathogenesis.

ABSTRACT: Calcific aortic valve disease sits at the confluence of multiple world-wide epidemics of aging, obesity, diabetes, and renal dysfunction, and its prevalence is expected to nearly triple over the next 3 decades. This is of particularly dire clinical relevance, as calcific aortic valve disease can progress rapidly to aortic stenosis, heart failure, and eventually premature death. Unlike in atherosclerosis, and despite the heavy clinical toll, to date, no pharmacotherapy has proven effective to halt calcific aortic valve disease progression, with invasive and costly aortic valve replacement representing the only treatment option currently available. This substantial gap in care is largely because of our still-limited understanding of both normal aortic valve biology and the key regulatory mec

SUBMITTER: Blaser MC 

PROVIDER: S-EPMC8095729 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature