Regimen simplification and medication adherence: Fixed-dose versus loose-dose combination therapy for type 2 diabetes.

ABSTRACT:

Background

Suboptimal patient adherence to pharmacological therapy of type 2 diabetes may be due in part to pill burden. One way to reduce pill burden in patients who need multiple medications is to use fixed-dose combinations. Our study aimed to compare the effects of fixed-dose combination versus loose-dose combination therapy on medication adherence and persistence, health care utilization, therapeutic safety, morbidities, and treatment modification in patients with type 2 diabetes over three years.

Methods

Using administrative data, we conducted a retrospective controlled cohort study comparing type 2 diabetes patients who switched from monotherapy to either a fixed-dose combination or a loose-dose combination. Adherence was assessed as the primary endpoint and calculate

SUBMITTER: Bohm AK 

PROVIDER: S-EPMC8096115 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature