Luminal A Breast Cancer Co-expression Network: Structural and Functional Alterations.

ABSTRACT: Luminal A is the most common breast cancer molecular subtype in women worldwide. These tumors have characteristic yet heterogeneous alterations at the genomic and transcriptomic level. Gene co-expression networks (GCNs) have contributed to better characterize the cancerous phenotype. We have previously shown an imbalance in the proportion of intra-chromosomal (cis-) over inter-chromosomal (trans-) interactions when comparing cancer and healthy tissue GCNs. In particular, for breast cancer molecular subtypes (Luminal A included), the majority of high co-expression interactions connect gene-pairs in the same chromosome, a phenomenon that we have called loss of trans- co-expression. Despite this phenomenon has been described, the functional implication of this specific ne

SUBMITTER: Garcia-Cortes D 

PROVIDER: S-EPMC8096206 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature