The Local Inflammatory Profile and Predictors of Treatment Success in Subarachnoid Neurocysticercosis.

ABSTRACT:

Background

Subarachnoid neurocysticercosis (SANCC) represents the most severe and difficult to treat form of neurocysticercosis. The inflammatory response contributes significantly to the morbidity and mortality of the disease. This study sought to understand the nature and evolution of the inflammation associated with SANCC, and evaluate for predictors of time to cure.

Methods

There were 16 subjects with SANCC (basilar cistern, sylvian fissure, and/or spinal involvement) during active infection who had cerebrospinal fluid (CSF) cytokine and chemokine profiling, of whom 9 had a second CSF sample at (or following) the time of cure. The relationships between clinical parameters and cytokine/chemokine results were assessed.

Results

Compared to pools of healthy donor CSF,

SUBMITTER: Harrison S 

PROVIDER: S-EPMC8096242 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature