Pilot multi-site and reproducibility study of hypothalamic gliosis in children.

ABSTRACT:

Objective

Quantitative magnetic resonance imaging (MRI) evidence of mediobasal hypothalamic (MBH) gliosis positively correlates with body mass index (BMI) in adults. This has neither been well explored in children nor have other brain regions involved in appetitive processing been tested for evidence of gliosis.

Methods

Multi-site cross-sectional study in children to test for differences in quantitative T2 signal (measure of gliosis) by region and to assess relationships with age and BMI. Participants underwent brain MRI using the same equipment and protocol to quantify T2 relaxation time in six bilateral regions of interest (ROIs): putamen, caudate, ventral striatum, amygdala, hippocampus and MBH, and three control regions: white matter, motor cortex and dorsal hypothalamus

SUBMITTER: Sewaybricker LE 

PROVIDER: S-EPMC8096323 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature