Epigenetic Age Acceleration and Chronic Health Conditions Among Adult Survivors of Childhood Cancer.

ABSTRACT:

Background

Mounting evidence supports the occurrence of accelerating aging among long-term survivors of childhood cancer. We aimed to investigate epigenetic age acceleration (EAA) in survivors and evaluate associations between EAA, treatment exposures, health behaviors, and chronic health conditions (CHCs).

Methods

Genome-wide methylation data were generated with Infinium EPIC BeadChip on blood-derived DNA from 2139 survivors and 282 frequency matched controls from the St Jude Lifetime Cohort Study. EAAs were estimated as residuals from a linear regression of epigenetic age (Levine's clock) against chronological age. Adjusted least square mean (ALSM) of EAA was calculated and compared between survivors and controls, across treatment exposures and health behaviors. Associatio

SUBMITTER: Qin N 

PROVIDER: S-EPMC8096366 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature