A Comparison of Late Mortality Among Survivors of Childhood Cancer in the United States and United Kingdom.

ABSTRACT:

Background

It is unclear whether late-effect risks among childhood cancer survivors vary internationally. We compared late mortality in the North American Childhood Cancer Survivor Study (CCSS) and British Childhood Cancer Survivor Study (BCCSS).

Methods

Late mortality was assessed among 49 822 5-year survivors of childhood cancer diagnosed before 15 years of age from 1970 to 1999 (CCSS, n = 31 596; BCCSS, n = 18 226) using cumulative mortality probabilities (CM%) and adjusted ratios of the standardized mortality ratio.

Results

The all-cause CM% at 10 years from diagnosis was statistically significantly lower in the CCSS (4.7%, 95% confidence interval [CI] = 4.5% to 5.0%) compared with the BCCSS (6.9%, 95% CI = 6.5% to 7.2%), attributable to a lower probability of dea

SUBMITTER: Fidler-Benaoudia MM 

PROVIDER: S-EPMC8096371 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature