Topical nitroglycerin ointment as salvage therapy for peripheral tissue ischemia in newborns: a systematic review.

ABSTRACT:

Background

Topical nitroglycerin (TNG) ointment has been used for almost 3 decades to treat neonatal peripheral tissue ischemia, but this product is now no longer being produced by its Canadian manufacturer. Our aim was to investigate the efficacy and safety of TNG products in newborns in neonatal intensive care units.

Methods

In this systematic review we searched Embase, CINAHL, MEDLINE, PubMed and Web of Science from inception to April 2020 for studies on the use of TNG products (TNG ointment, TNG spray, glyceryl trinitrate [GTN] patch) for the treatment of neonatal tissue ischemia. We did not apply language or study design limitations. Animal studies and duplicate records were excluded. Two reviewers screened and extracted data. The Tool for Evaluating the Methodological

SUBMITTER: Sushko K 

PROVIDER: S-EPMC8096410 | biostudies-literature | 2021 Jan-Mar

REPOSITORIES: biostudies-literature