Association Between Immune Response to Cytomegalovirus and Cognition in the Health and Retirement Study.

ABSTRACT: Chronic infections and the subsequent immune response have recently been shown to be risk factors for cognitive decline and Alzheimer disease and related dementias (ADRD). While some studies have shown an association between cytomegalovirus (CMV), a chronic and highly prevalent infection, and cognition and/or ADRD, these studies have been limited by nonrepresentative and small samples. Using 2016 data on 5,617 adults aged 65 years or more from the Health and Retirement Study, we investigated the cross-sectional associations of both CMV serostatus and immunoglobulin G (IgG) antibody response with cognitive function using linear regression models adjusting for age, sex, race/ethnicity, and educational attainment. We further investigated potential effect-measure modification by educational at

SUBMITTER: Stebbins RC 

PROVIDER: S-EPMC8096487 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature