Nephrotic syndrome disease activity is proportional to its associated hypercoagulopathy.

ABSTRACT:

Introduction

Nephrotic syndrome (NS) is associated with an acquired hypercoagulopathy that drives its strong predilection for life-threatening thrombosis. We previously demonstrated that hypercoagulopathy is proportional to NS disease severity in animal models. Therefore, hypercoagulopathy and disease severity may inform thrombosis risk and better guide therapeutic decision making. The objective of this study was thus to establish the relationship between disease severity and hypercoagulopathy in human NS.

Materials and methods

Thrombin generation assays (TGA) were performed on biorepository plasma samples from a prospective longitudinal NS cohort study. TGA was also determined on a separate cohort of incident NS patients. Multivariable regression was used to build NS-hyperc

SUBMITTER: Waller AP 

PROVIDER: S-EPMC8096658 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature