Biomarkers of phthalates and inflammation: Findings from a subgroup of Women's Health Initiative participants.

ABSTRACT:

Background

Recent experimental work has shown that phthalates may increase inflammation. Prior research has not examined the role of exposure to phthalates in relation to inflammatory status among postmenopausal women who are at higher risk of developing inflammation-related chronic disorders.

Objectives

We aimed to examine the associations of urinary phthalate biomarker concentrations with circulating levels of c-reactive protein [CRP] and interleukin-6 [IL-6] among 443 postmenopausal women selected into a breast cancer case-control study nested within the Women's Health Initiative (WHI).

Methods

A total of 13 phthalate metabolites were measured in urine samples provided at WHI enrollment from 1993 to 1998. We also measured baseline levels of CRP and IL-6 in these wo

SUBMITTER: Trim A 

PROVIDER: S-EPMC8096686 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature