Inducible phospholipid transfer protein deficiency ameliorates atherosclerosis.

ABSTRACT:

Background and aims

Atherosclerosis progression and regression studies are related to its prevention and treatment. Although we have gained extensive knowledge on germline phospholipid transfer protein (PLTP) deficiency, the effect of inducible PLTP deficiency in atherosclerosis remains unexplored.

Methods

We generated inducible PLTP (iPLTP)-knockout (KO) mice and measured their plasma lipid levels after feeding a normal chow or a Western-type diet. Adenovirus associated virus-proprotein convertase subtilisin/kexin type 9 (AAV-PCSK9) was used to induce hypercholesterolemia in the mice. Collars were placed around the common carotid arteries, and atherosclerosis progression and regression in the carotid arteries and aortic roots were evaluated.

Results

On a normal chow

SUBMITTER: Zhang K 

PROVIDER: S-EPMC8096707 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature