Short-Chain Fatty Acids Outpace Ketone Oxidation in the Failing Heart.

ABSTRACT:

Background

The failing heart is energy starved with impaired oxidation of long-chain fatty acids (LCFAs) at the level of reduced CPT1 (carnitine palmitoyltransferase 1) activity at the outer mitochondrial membrane. Recent work shows elevated ketone oxidation in failing hearts as an alternate carbon source for oxidative ATP generation. We hypothesized that another short-chain carbon source, short-chain fatty acids (SCFAs) that bypass carnitine palmitoyltransferase 1, could similarly support energy production in failing hearts.

Methods

Cardiac hypertrophy and dysfunction were induced in rats by transverse-aortic constriction (TAC). Fourteen weeks after TAC or sham operation, isolated hearts were perfused with either the 4 carbon, ¹³C-labeled ketone (D3-hydroxybutyra

SUBMITTER: Carley AN 

PROVIDER: S-EPMC8096711 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature