Dopamine-related striatal neurophysiology is associated with specialization of frontostriatal reward circuitry through adolescence.

ABSTRACT: Characterizing developmental changes in frontostriatal circuitry is critical to understanding adolescent development and can clarify neurobiological mechanisms underlying increased reward sensitivity and risk-taking and the emergence of psychopathology during this period. However, the role of striatal neurobiology in the development of frontostriatal circuitry through human adolescence remains largely unknown. We examined background connectivity during a reward-guided decision-making task ("reward-state"), in addition to resting-state, and assessed the association between age-related changes in frontostriatal connectivity and age-related changes in reward learning and risk-taking through adolescence. Further, we examined the contribution of dopaminergic processes to changes in frontostriat

SUBMITTER: Parr AC 

PROVIDER: S-EPMC8096717 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature