Neuroplastin expression is essential for hearing and hair cell PMCA expression.

ABSTRACT: Hearing deficits impact on the communication with the external world and severely compromise perception of the surrounding. Deafness can be caused by particular mutations in the neuroplastin (Nptn) gene, which encodes a transmembrane recognition molecule of the immunoglobulin (Ig) superfamily and plasma membrane Calcium ATPase (PMCA) accessory subunit. This study investigates whether the complete absence of neuroplastin or the loss of neuroplastin in the adult after normal development lead to hearing impairment in mice analyzed by behavioral, electrophysiological, and in vivo imaging measurements. Auditory brainstem recordings from adult neuroplastin-deficient mice (Nptn^-/-) show that these mice are deaf. With age, hair cells and spiral ganglion cells degenerate in Nptn^-/-<

SUBMITTER: Lin X 

PROVIDER: S-EPMC8096745 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature