Evidence gap on antihyperglycemic pharmacotherapy in frail older adults : A systematic review.

ABSTRACT:

Background

Although antihyperglycemic pharmacotherapy in frail older adults with type 2 diabetes mellitus (T2DM) is challenging, recommendations from international guidelines are mainly based on indirect evidence from trials not including frail participants.

Objective

This systematic review investigated the effectiveness and safety of pharmacotherapy in frail older adults with T2DM.

Material and methods

Randomized (RCT) and non-randomized prospective clinical trials (non-RCT) were searched in three electronic databases (Medline, Embase, Central) up to October 2018. Trials in older adults with T2DM who were assessed as significantly or severely impaired by defined cut-off scores of assessment instruments on frailty, activities of daily living or physical functional imp

SUBMITTER: Bollig C 

PROVIDER: S-EPMC8096761 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature