Sustained absorption of delamanid from lipid-based formulations as a path to reduced frequency of administration.

ABSTRACT: Delamanid is a poorly water-soluble drug currently being used for the treatment of tuberculosis. The high frequency of dosing leads to poor adherence for patients who live in lower economic and nomadic populations. Non-digestible self-assembling lipids as a formulation approach for poorly water-soluble drugs have previously been shown to extend the window of absorption through gastric retention. We hypothesise that this approach could lead to the reduction of dosing frequency for delamanid and thereby has potential to improve adherence. Formulations of delamanid were prepared in selachyl alcohol and phytantriol as non-digestible self-assembling lipid vehicles, and their behaviour was compared with reconstituted milk powder, as a digestible lipid-based formulation, and an aqueous suspension

SUBMITTER: Ramirez G 

PROVIDER: S-EPMC8096769 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature