Genetic factors affect the susceptibility to bacterial infections in diabetes.

ABSTRACT: Diabetes increases the risk of bacterial infections. We investigated whether common genetic variants associate with infection susceptibility in Finnish diabetic individuals. We performed genome-wide association studies and pathway analysis for bacterial infection frequency in Finnish adult diabetic individuals (FinnDiane Study; N = 5092, Diabetes Registry Vaasa; N = 4247) using national register data on antibiotic prescription purchases. Replication analyses were performed in a Swedish diabetic population (ANDIS; N = 9602) and in a Finnish non-diabetic population (FinnGen; N = 159,166). Genome-wide data indicated moderate but significant narrow-sense heritability for infection susceptibility (h² = 16%, P = 0.02). Variants on chromosome 2 were associated with reduced infection su

SUBMITTER: Simonsen JR 

PROVIDER: S-EPMC8096814 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature