¹²⁵I Seed Promotes Apoptosis in Non-small Lung Cancer Cells via the p38 MAPK-MDM2-p53 Signaling Pathway.

ABSTRACT: Purpose: ¹²⁵I seeds were effective in the treatment of non-small cell lung cancer in previous research. However, the exact signaling pathway-mediated apoptosis mechanism is still unclear. The present study analyzed the effects and potential mechanisms of ¹²⁵I seed on the growth and migration of A549 cells. Methods: Lung cancer A549 cells were irradiated with ¹²⁵I seed for various times. MTT, invasion assay, and flow cytometry were used to detect the proliferation, invasion, and apoptosis of treated cells, respectively. A Nimblegen genome-wide expression profile chip was used to evaluate gene expression changes in ¹²⁵I seed-treated A549 cells. Validation studies were performed using phosphorylated protein chip technology, Western blo

SUBMITTER: Zhang T 

PROVIDER: S-EPMC8096899 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature